Overexpression of a conserved HSP40 chaperone reduces toxicity of several neurodegenerative disease proteins
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چکیده
منابع مشابه
Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model of ALS exhibiting TDP-43 dependent toxicity, we now show that TDP-43 overexpression dramatically alters cell shape and reduces ubiquitin dependent proteolysis of a reporter co...
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Protein misfolding is implicated in numerous lethal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). There are no therapies that reverse these protein-misfolding events. We aim to apply Hsp104, a hexameric AAA+ protein from yeast, to target misfolded conformers for reactivation. Hsp104 solubilizes disordered aggregates and amyloid, but has l...
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ژورنال
عنوان ژورنال: Prion
سال: 2018
ISSN: 1933-6896,1933-690X
DOI: 10.1080/19336896.2017.1423185